I have spent a lot of time with friends and alone testing resolution of MF and LF lenses as part of real world camera systems. One of the big limitations for putting anything to film has been the resolution limits of the film itself and diffraction at smaller apertures.
In their own way, if I'm reading this correctly, nothing has changed when it comes to digital photography. Check out this article and see what you think.
The optical sensor in a CCD or CMOS array becomes the limiting "airy disk" and optical diffraction limits how far you can stop down. I'm happy to see that the laws of physics remain in full effect.